Hydrochloric Acid → 2-Methyl-7-nitro-3-propionylbenzo[b]furan

HRID 342422

反応式

HRID 342422 の反応式
[CH3:1][C:2]1[O:6][C:5]2[C:7]([N+:11]([O-:13])=[O:12])=[CH:8][CH:9]=[CH:10][C:4]=2[CH:3]=1.[Cl-].[Al+3].[Cl-].[Cl-].[C:18](Cl)(=[O:21])[CH2:19][CH3:20].Cl>ClCCl>[CH3:1][C:2]1[O:6][C:5]2[C:7]([N+:11]([O-:13])=[O:12])=[CH:8][CH:9]=[CH:10][C:4]=2[C:3]=1[C:18](=[O:21])[CH2:19][CH3:20]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 62324Propionyl chlorideHCID 6451240Aluminum(III) ChlorideHCID 132018972-Methyl-7-nitrobenzofuran

生成物 1

HCID 701967632-Methyl-7-nitro-3-propionylbenzo[b]furan

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a mixture of 2-methyl-7-nitrobenzo[b]furan (177 mg) and aluminum chloride (200 mg) in dichloromethane (5 ml) was added dropwise propionyl chloride (0.18 ml). The mixture was stirred at ambient temperature for 3 hours and poured into a mixture of ice and 1N-hydrochloric acid. The separated oil was extracted with dichloromethane and the extract was washed with brine, dried over sodium sulfate and evaporated in vacuo. The residue was crystallized from diethyl ether to give 2-methyl-7-nitro-3-propionylbenzo[b]furan (215 mg).

後処理

  1. extractionThe separated oil was extracted with dichloromethane
  2. washthe extract was washed with brine
  3. dry with materialdried over sodium sulfate
  4. customevaporated in vacuo
  5. customThe residue was crystallized from diethyl ether

出典と根拠

ORDレコード
ord-1b3f6cc5efa24c4bb6df4f996b507601
出典データセット
uspto-grants-1999_01
特許番号
US05858995

関連ノート

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