Hydrochloric Acid → HCID 70201449、化合物
反応式
[Cl:1][C:2]1[CH:24]=[CH:23][CH:22]=[C:21]([Cl:25])[C:3]=1[C:4]([NH:6][C:7]1[C:12]2[O:13][C:14]([CH3:20])=[C:15]([C:16](O)([CH3:18])[CH3:17])[C:11]=2[CH:10]=[CH:9][CH:8]=1)=[O:5].Cl>C(OCC)(=O)C>[Cl:1][C:2]1[CH:24]=[CH:23][CH:22]=[C:21]([Cl:25])[C:3]=1[C:4]([NH:6][C:7]1[C:12]2[O:13][C:14]([CH3:20])=[C:15]([C:16]([CH3:18])=[CH2:17])[C:11]=2[CH:10]=[CH:9][CH:8]=1)=[O:5]参加物
4
実験手順
A solution of 7-(2,6-dichlorobenzoylamino)-3-(1-hydroxy-1-methylethyl)-2-methylbenzo[b]furan (150 mg) in 4N-hydrogenchloride in ethyl acetate was refluxed for 2 hours. The reaction mixture was concentrated in vacuo and the residue was purified by column chromatography on silica gel. The obtained oil was crystallized from a mixture of diethyl ether and hexane to give 7-(2,6-dichlorobenzoylamino)-2-methyl-3-(1-methylvinyl)benzo[b]furan (72 mg).