1-(3-chloropropyl)-5-methyl-2,4(1H,3H)-pyrimidinedione → 1-(3-{4-[4-chloro-2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propyl)-5-methyl-2,4(1H,3H)-pyrimidinedione hydrochloride

反応式

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[C:4]([O:14][CH2:15][C:16]([F:19])([F:18])[F:17])[CH:3]=1.Cl[CH2:21][CH2:22][CH2:23][N:24]1[CH:29]=[C:28]([CH3:30])[C:27](=[O:31])[NH:26][C:25]1=[O:32]>>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][N:11]([CH2:21][CH2:22][CH2:23][N:24]3[CH:29]=[C:28]([CH3:30])[C:27](=[O:31])[NH:26][C:25]3=[O:32])[CH2:10][CH2:9]2)=[C:4]([O:14][CH2:15][C:16]([F:18])([F:17])[F:19])[CH:3]=1

参加物

反応物 2

HCID 120913751-(3-chloropropyl)-5-methyl-2,4(1H,3H)-pyrimidinedione

HCID 158406641-[4-Chloro-2-(2,2,2-trifluoroethoxy)phenyl]piperazine

生成物 1

HCID 702029871-(3-{4-[4-chloro-2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propyl)-5-methyl-2,4(1H,3H)-pyrimidinedione hydrochloride

実験手順

substituting 1-[4-chloro-2-(2,2,2-trifluoroethoxy)phenyl]piperazine and 1-(3-chloropropyl)-5-methyl-2,4(1H,3H)-pyrimidinedione gave 1-(3-{4-[4-chloro-2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propyl)-5-methyl-2,4(1H,3H)-pyrimidinedione hydrochloride, m.p. 205°-206° C.; Anal.: Calcd. for C20H24ClF3N4O3.(HCl)2 : C, 43.53; H, 5.10; N, 10.15%; Found: C, 43.77; H, 5.10; N, 10.13%;

出典と根拠

ORDレコード: ord-6625c4dddb584b118047ded12014b4cb
出典データセット: uspto-grants-1999_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05859014

反応ノート

読み込み中…