関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | 4-(Trifluoromethyl)cinnamic acid | HCID 688070 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-(Trifluoromethyl)cinnamoyl chloride | HCID 11107291 | — |
反応手順
Thionyl chloride (335 ml, 4.6 mmol) was added at 0° C. to 4-trifluoromethyl-E-cinnamic acid (1 g, 4.6 mmol) and pyridine (375 ml, 4.6 mmol) in dry CH2Cl2. The mixture was then stirred for 1 h without cooling, again cooled to 0° C. and filtered with the exclusion of moisture. The filtrate (10 ml) contained the title compound and was used in aliquots for the next reaction step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05859025 |
|---|
| 出典データセット | uspto-grants-1999_01 |
|---|
| ORD ID | ord-548f034edc534529847ea7bcc3e082ba |
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| 出典メモ | uspto-grants-1999_01 |
|---|
