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Water → 4-Methylsulfonylacetophenone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Ethylenediaminetetraacetic Acid | HCID 6049 | — |
| 反応物 | 1-(4-Methyl-2-thienyl)ethan-1-one | HCID 83654 | — |
| 反応物 | Sodium Pyrosulfite | HCID 656671 | — |
| 反応物 | Potassium hydroxy sulfite | HCID 23707502 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 4-Methylsulfonylacetophenone | HCID 82529 | — |
反応手順
A solution of 1036 g of oxone and 11.7 g of EDTA (Ethylene diamine tetraacetic acid) dissolved in 3.8 l of water is added dropwise to a solution of (4-methylthiophenyl)ethanone (prepared according to J. Am. Chem. Soc. 1952 p. 5475) in 1 l of acetone and 1.1 l of water, the temperature being kept below 32° C. The reaction mixture is stirred for 16 h after the end of the addition, then 550 g of sodium metabisulphite are added portionwise. The reaction mixture is then filtered, the solid obtained is taken up in water, dried in the oven and recrystallised from ethanol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05859036 |
| 出典データセット | uspto-grants-1999_01 |
| ORD ID | ord-9d0b9ce9dd594b1b83638059fc6fe3bc |
| 出典メモ | uspto-grants-1999_01 |