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Iodoethane → HCID 12515028、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Iodoethane | HCID 6340 | — |
| 反応物 | Tetramethylammonium Hydroxide Pentahydrate | HCID 82620 | — |
| 反応物 | BOC-D-alanine | HCID 637606 | — |
| 反応物 | N-(12-methoxy-1-oxododecyl)-D-alanine, ethyl ester | HCID 15870267 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | HCID 12515028 | HCID 12515028 | — |
反応手順
Reaction Scheme 6 illustratively shows the preparation of N-(12-methoxy-1-oxododecyl)-D-alanine, ethyl ester wherein N-(t-butyloxycarbonyl)-D-alanine (16) is treated with tetramethylammonium hydroxide pentahydrate in acetonitrile followed by the addition of ethyl iodide to form N-(t-butyloxycarbonyl)-D-alanine, ethyl ester (17) which in turn reacts with trifluoroacetic acid in methylene chloride to give the trifluoroacetate salt of D-alanine ethyl ester (18) which, when treated with 2-methoxydodecanoyl chloride (9) in methylene chloride, gives the desired fatty acid amino ester (19).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05859052 |
| 出典データセット | uspto-grants-1999_01 |
| ORD ID | ord-c9943100722e477b81ddb31f495ec7d2 |
| 出典メモ | uspto-grants-1999_01 |