4-Chlorobiphenyl → 2-(2-Iodophenyl)ethan-1-ol

HRID 342735

反応式

HRID 342735 の反応式
[I:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH2:9]Br.ClC1C=CC(C2C=CC=CC=2)=CC=1.C(OCCCC1C=CC=CC=1)(=O)CC([O-])=[O:27]>>[I:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH2:9][OH:27]

参加物

4

反応物 3

HCID 163234-ChlorobiphenylHCID 110778011-(2-Bromoethyl)-2-iodobenzeneHCID 86753570Phenylpropyl malonate

生成物 1

HCID 110647502-(2-Iodophenyl)ethan-1-ol

実験手順

The title compound was synthesized by a sequence similar to that for Example 87 except that 2-(2-iodophenyl)ethyl bromide and commercially available diethyl phenethyl malonate were used in lieu of the 4-chlorobiphenyl and phenylpropyl malonate respectively. The final product was recrystallized from chloroform to give a fluffy, white solid (mp: melts/softens over a broad range starting at 50° C.; the bulk of the sample melts at 189°-190° C.).

後処理

  1. customThe final product was recrystallized from chloroform
  2. customto give a fluffy, white solid (mp
  3. customstarting at 50° C.

出典と根拠

ORDレコード
ord-71d7ed8437944441b80141fbeb217025
出典データセット
uspto-grants-1999_01
特許番号
US05859047

関連ノート

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