Hydrogen Bromide → methyl N-(2-oxo-tetrahydrofur-3-yl)aminoacetate

関与物質

役割	名称	HCID	仕込み量
反応物	Hydrogen Bromide	HCID 260	—
反応物	Homoserine Lactone	HCID 73509	—
反応物	Potassium Bromide	HCID 253877	—
溶媒	Chloroform	HCID 6212	—
生成物	methyl N-(2-oxo-tetrahydrofur-3-yl)aminoacetate	HCID 43825791	31%

反応手順

This compound (9) was synthesized from (±)-α-amino-γ-butyrolactone×HBr using a method analogous to the synthesis described in Example 4. FC (silica gel, CHCl3). Yield: 31%. IR (KBr): 3333 (N--H), 1770, 1740 (C=O), 1216, 1165 (C--O). 1H-NMR (CDCl3): 2.05-2.18 (m, 1H); 2.47-2.57 (m, 1H); 3.57 (d, J=17.6, 1H); 3.63 (d, J=17.6, 1H); 3.64 (dd, J=8.1, 9.8, 1H); 3.75 (s, 3H); 4.21 (dt, J=6.3, 9.8, 1H); 4.42 (dt, J=2.3, 8.8, 1H).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US05859215
出典データセット	uspto-grants-1999_01
ORD ID	ord-c0136769771447789134f00649300e55
出典メモ	uspto-grants-1999_01