化工社化工社 化学情報印刷レポート · 研究参考用
L-Phenylalanine → (3s)-3-Amino-2-hydroxy-4-phenylbutanoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | L-Phenylalanine | HCID 6140 | — |
| 反応物 | Phthalic Anhydride | HCID 6811 | — |
| 反応物 | (2S)-2-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)-3-phenylpropanoic acid | HCID 334207 | — |
| 反応物 | 3-phenyl-2(S)-phthalimidopropionyl chloride | HCID 10567197 | — |
| 反応物 | 3-Phenyl-2(S)-phthalimidopropan-1-al | HCID 11065801 | — |
| 反応物 | 1-cyano-3-phenyl-2(S)-phthalimidopropan-1-ol | HCID 15289369 | — |
| 生成物 | (3s)-3-Amino-2-hydroxy-4-phenylbutanoic acid | HCID 10856377 | — |
反応手順
L-phenylalanine of the formula ##STR2## is reacted with phthalic anhydride, b) the resultant 3-phenyl-2(S)-phthalimidopropionic acid of the formula ##STR3## is converted into the corresponding acid chloride, c) the resultant 3-phenyl-2(S)-phthalimidopropionic acid chloride of the formula ##STR4## is reduced, d) the resultant 3-phenyl-2(S)-phthalimidopropan-1-al of the formula ##STR5## is transformed into the 1-cyano-3-phenyl-2(S)-phthalimidopropan-1-ol of the formula ##STR6## e) the resultant nitrile of the formula VI is hydrolysed, f) the 3(S)-amino-2-hydroxy-4-phenylbutyric acid formed of the formula ##STR7## is reacted with a low alkyl ester or the phenyl or benzyl ester of chloroformic acid,
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05859248 |
| 出典データセット | uspto-grants-1999_01 |
| ORD ID | ord-6b9f43ca2ed44bd786c5520f96380fce |
| 出典メモ | uspto-grants-1999_01 |