Hydrazine → HCID 178498201、化合物

HRID 343129ノート

反応式

HRID 343129 の反応式
[CH3:1][C:2]([CH2:4][C:5]([C:7]([O:9][CH3:10])=[O:8])=O)=O.[NH2:11][NH2:12]>C(O)C>[CH3:10][O:9][C:7]([C:5]1[NH:11][N:12]=[C:2]([CH3:1])[CH:4]=1)=[O:8]

参加物

4

反応物 2

HCID 9321HydrazineHCID 88600Methyl acetopyruvate

生成物 1

HCID 178498201HCID 178498201、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a stirring solution of 2.0 g (13.87 mmol) of methyl acetopyruvate in 40 mL of absolute ethanol at 0° C. is added 0.48 mL (15.27 mmol, 1.1 equiv) of hydrazine. The resultion solution is stirred for 1 h at RT then heated to reflux for 3 h. The solution is then cooled to RT and the solvent removed in vacuo to give 5-methyl-2H-pyrazole-3-carboxylic acid methyl ester as a clear yellow oil which is used without further purification: 1H NMR (CDCl3, 300 MHz) δ6.61 (s, 1H), 3.97 (s, 3H),2.40 (s, 3H).

後処理

  1. temperaturethen heated
  2. temperatureto reflux for 3 h
  3. temperatureThe solution is then cooled to RT
  4. customthe solvent removed in vacuo

出典と根拠

ORDレコード
ord-1c77bde0484043aea58f1ef7cacae819
出典データセット
uspto-grants-1999_01
特許番号
US05859007

反応ノート

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