Phosphorus oxychloride → HCID 54002462、化合物

反応式

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:13](=O)[N:12]=[C:11]([CH3:15])[N:10]=2)=[CH:5][CH:4]=1.P(Cl)(Cl)([Cl:18])=O>>[Cl:18][C:13]1[NH:12][C:11]([CH3:15])=[N:10][C:9]=1[C:6]1[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=1

参加物

反応物 2

HCID 24813Phosphorus oxychloride

HCID 57217469HCID 57217469、化合物

生成物 1

HCID 54002462HCID 54002462、化合物

実験手順

A stirred solution of 10.0 grams (0.049 mole) of 4-(4-methoxyphenyl)-2-methyl-imidazol-5-one in 50 mL of phosphorous oxychloride is heated at reflux for about three hours. After this time, the reaction mixture is concentrated under reduced pressure, yielding 5-chloro-4-(4-methoxyphenyl)-2-methylimidazole.

後処理

temperatureat reflux for about three hours
concentrationAfter this time, the reaction mixture is concentrated under reduced pressure

出典と根拠

ORDレコード: ord-18224d0ddf644d30913b961644da0277
出典データセット: uspto-grants-1999_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05861359

反応ノート

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