Benzaldehyde → XR 334

HRID 343297ノート

反応式

HRID 343297 の反応式
C([N:4]1[CH2:9][C:8](=[O:10])[NH:7]/[C:6](=[CH:11]\[C:12]2[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=2)/[C:5]1=[O:20])(=O)C.[CH:21](=O)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.C(N(CC)CC)C.C(OCC)(=O)C>CN(C=O)C>[CH:21](=[C:9]1/[C:8](=[O:10])[NH:7]/[C:6](=[CH:11]\[C:12]2[CH:13]=[CH:14][C:15]([O:18][CH3:19])=[CH:16][CH:17]=2)/[C:5](=[O:20])[NH:4]/1)\[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

参加物

6

反応物 4

HCID 240BenzaldehydeHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 5392210HCID 5392210、化合物

生成物 1

HCID 9797139XR 334

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
130 °C

実験手順

A mixture of (3Z)-1-acetyl-3-(4-methoxybenzylidene)-2,5-piperazinedione (9) (1.0 g, 3.6 mmol), benzaldehyde (430 μl, 4.2 mmol) and triethylamine (1.14 ml), 8.2 mmol), in dry DMF (20 ml), was heated at 130° C. for 18 h. The reaction mixture was cooled to room temperature and poured into ethyl acetate (100 ml). A yellow solid precipitated which was filtered off and dried. Yield 360 mg (31%).

後処理

  1. temperatureThe reaction mixture was cooled to room temperature
  2. customA yellow solid precipitated which
  3. filtrationwas filtered off
  4. customdried

出典と根拠

ORDレコード
ord-8fbb5351fced4ac286c19de3f90f93d2
出典データセット
uspto-grants-1999_01
特許番号
US05861400

反応ノート

読み込み中…