Methane → epsilon(4-Amino 2-methoxy-benzenesulfonamido)caproic acid

HRID 34332ノート

反応式

HRID 34332 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10]([NH:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([OH:21])=[O:20])(=[O:12])=[O:11])=[C:6]([O:22][CH3:23])[CH:5]=1)([O-])=O.C>C(OCC)(=O)C>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([S:10]([NH:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([OH:21])=[O:20])(=[O:11])=[O:12])=[C:6]([O:22][CH3:23])[CH:5]=1

参加物

4

反応物 2

HCID 297MethaneHCID 13192117epsilon(4-Nitro 2-methoxy-benzenesulfonamido)caproic acid

生成物 1

HCID 13192164epsilon(4-Amino 2-methoxy-benzenesulfonamido)caproic acid収率 98%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

A solution of ε(4-nitro 2-methoxy-benzenesulfonamido) caproic acid (1.4 g) in solution in ethyl acetate (150 cm3) is stirred magnetically under a hydrogen atmosphere in the presence of 5% palladized charcoal (120 mg). After four hours, the hydrogen absorption being terminated, the catalyst is filtered and the filtrate concentrated under reduced pressure. Pure ε(4-amino 2-methoxy-benzenesulfonamido) caproic acid is obtained, with a yield of 98%.

後処理

  1. customthe hydrogen absorption
  2. custombeing terminated
  3. filtrationthe catalyst is filtered
  4. concentrationthe filtrate concentrated under reduced pressure

出典と根拠

ORDレコード
ord-938d3588ccc346198d391010c2494c35
出典データセット
uspto-grants-1988_08
特許番号
US04761430

反応ノート

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