Acetone → 1-(4-Bromophenyl)-4-ethoxybenzene

HRID 343461ノート

反応式

HRID 343461 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.C([O-])([O-])=O.[K+].[K+].[CH3:21][C:22](C)=O>O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH2:21][CH3:22])=[CH:10][CH:9]=2)=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 180AcetoneHCID 11430Potassium CarbonateHCID 950934-Bromo-4'-hydroxybiphenyl

生成物 1

HCID 158408841-(4-Bromophenyl)-4-ethoxybenzene収率 91%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a solution of 4-(4-bromophenyl)-phenol (4.06 g, 16.3 mmol) in acetone (30 mL) at room temperature, was added 4.5 eq K2CO3 (4.0M, 18 mL, 73.3 mmol) in water and 4.0 eq lodoethane (5.26 mL, 65.2 mmol). The reaction mixture was stirred overnight, and heated to reflux for 6 hrs. The product was crystallized out of the solution, and filtered. The crude product was recrystallized from hexane to provide ethyl 4-(4-bromophenyl) phenyl ether (4.1 g, 91%) as an white crystal.

後処理

  1. temperatureheated
  2. temperatureto reflux for 6 hrs
  3. customThe product was crystallized out of the solution
  4. filtrationfiltered
  5. customThe crude product was recrystallized from hexane

出典と根拠

ORDレコード
ord-b1ff756046424cdabb2334e260147684
出典データセット
uspto-grants-1999_01
特許番号
US05861428

反応ノート

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