Triethylamine → HCID 11436590、化合物

HRID 343600

反応式

HRID 343600 の反応式
[CH2:1]([NH:3][CH2:4][C:5]([OH:7])=O)[CH3:2].[CH3:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH3:15])[C:10]=1[N:16]=[C:17]=[S:18].C(N(CC)CC)C>C(Cl)Cl>[CH3:15][C:11]1[CH:12]=[CH:13][CH:14]=[C:9]([CH3:8])[C:10]=1[N:16]1[C:5](=[O:7])[CH2:4][N:3]([CH2:1][CH3:2])[C:17]1=[S:18]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 879762,6-Xylyl isothiocyanateHCID 316542N-Ethylglycine

生成物 1

HCID 11436590HCID 11436590、化合物収率 18.4%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A mixture of N-ethyl glycine (9.2 g), 2,6-dimethylphenyl-isothiocyanate (8.2 g), triethylamine (10.1 g), and methylene chloride (150 mL) was heated at reflux for 3.5 hours. The mixture was evaporated to dryness. Purification was achieved through crystallization from ethanol. The title compound (2.3 g) was obtained as a white solid (2.3 g). m.p. 128°-131° C. Anal. Calcd. for. C13H16N2OS: C, 62.87; H, 6.49; N, 11.28. Found: C, 62.83; H, 6.50; N, 11.25. Mass spectrum (EI, M.+) m/z 248.

後処理

  1. temperaturewas heated
  2. temperatureat reflux for 3.5 hours
  3. customThe mixture was evaporated to dryness
  4. customPurification
  5. customwas achieved through crystallization from ethanol

出典と根拠

ORDレコード
ord-497f500330044158bb46447d68ff46cf
出典データセット
uspto-grants-1999_01
特許番号
US05861517

関連ノート

読み込み中…