関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Cyanide | HCID 9032 | — |
| 反応物 | Ammonium Carbonate | HCID 517111 | — |
| 反応物 | Water ethanol | HCID 19096565 | — |
| 反応物 | 4-Cyano-2-(2-phenylethynyl)benzaldehyde | HCID 54356802 | — |
| 生成物 | 5-[4-Cyano-2-(2-phenylethynyl)phenyl]hydantoin | HCID 70076578 | — |
反応手順
A stirred mixture of 4-cyano-2-(2-phenylethynyl)benzaldehyde (0.69 g, 3.0 mmol), potassium cyanide (0.39 g, 6.0 mmol) and ammonium carbonate (1.15 g, 12 mmol) in ethanol-water (1:1, 12 ml) was heated to 85° C. for 4 hours following the procedure described in Example 1 (ii). The crude solid obtained after extraction was chromatographed on flash silica eluting with ether to give 5-[4-cyano-2-(2-phenylethynyl)phenyl]hydantoin as a yellow foam.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05863947 |
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| 出典データセット | uspto-grants-1999_01 |
|---|
| ORD ID | ord-b7fce059eeff4c118f86826b9ab8acd1 |
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| 出典メモ | uspto-grants-1999_01 |
|---|
