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Benzyl Chloride → Methyl 2-(4-benzyloxyphenyl)acetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzyl Chloride | HCID 7503 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Benzeneacetic acid, 4-hydroxy-, methyl ester | HCID 518900 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Methyl 2-(4-benzyloxyphenyl)acetate | HCID 2756645 | — |
反応手順
Methyl 4-hydroxyphenylacetate (5, 0.2 mol), obtainable from Aldrich Chemical Co. Inc., Milwaukee, Wis., is heated at reflux with benzyl chloride (25 g, 0.2 mol) and K2CO3 (25 g, 0.2 mol) in 100 mL ethanol. The product is added to dilute aqueous NaOH, extracted with ether, and purified by silica gel chromatography to yield methyl 4-benzyloxyphenylacetate (6). (Scheme II, Step 1.)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04761420 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-9c76812738bd47cb8d4850477591476a |
| 出典メモ | uspto-grants-1988_08 |