Benzyl Chloride → Methyl 2-(4-benzyloxyphenyl)acetate

HRID 34404

反応式

HRID 34404 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[CH:4][CH:3]=1.[CH2:13](Cl)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.C([O-])([O-])=O.[K+].[K+].[OH-].[Na+]>C(O)C>[CH2:13]([O:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[CH:6][CH:7]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

参加物

6

反応物 4

HCID 7503Benzyl ChlorideHCID 11430Potassium CarbonateHCID 14798Sodium HydroxideHCID 518900Benzeneacetic acid, 4-hydroxy-, methyl ester

生成物 1

HCID 2756645Methyl 2-(4-benzyloxyphenyl)acetate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Methyl 4-hydroxyphenylacetate (5, 0.2 mol), obtainable from Aldrich Chemical Co. Inc., Milwaukee, Wis., is heated at reflux with benzyl chloride (25 g, 0.2 mol) and K2CO3 (25 g, 0.2 mol) in 100 mL ethanol. The product is added to dilute aqueous NaOH, extracted with ether, and purified by silica gel chromatography to yield methyl 4-benzyloxyphenylacetate (6). (Scheme II, Step 1.)

後処理

  1. temperature, is heated
  2. extractionextracted with ether
  3. custompurified by silica gel chromatography

出典と根拠

ORDレコード
ord-9c76812738bd47cb8d4850477591476a
出典データセット
uspto-grants-1988_08
特許番号
US04761420

関連ノート

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