化工社化工社 化学情報印刷レポート · 研究参考用
Oxalic Acid → 4-(2-Tetrahydropyran-2-yloxyethyl)phenol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Oxalic Acid | HCID 971 | — |
| 反応物 | 3,4-dihydro-2H-pyran | HCID 8080 | — |
| 反応物 | Tyrosol | HCID 10393 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Sodium Sulfate | HCID 24436 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-(2-Tetrahydropyran-2-yloxyethyl)phenol | HCID 14208783 | — |
反応手順
Oxalic acid (64 g, 0.5 mol), Na2SO4 (400 g) and distilled dihydropyran (600 mL) are added to a solution of 4-(2-hydroxyethyl)phenol (600 g, 4.3 mol) in acetone (3 l) and the mixture stirred for 3 hours. The resulting solution is added to water (4 l) containing 35% NaOH solution (500 mL), and washed with CH2Cl2 (2X). The mixture was stirred vigorously for one hour. The organic phase was washed with water (3×1 l) and evaporated to yield 4-(2-tetrahydropyran-2-yloxyethyl)phenol (9).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04761420 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-1d2b9189a80b40619fd519eb29ed46e4 |
| 出典メモ | uspto-grants-1988_08 |