Hydrochloric Acid → 6-Bromo-1-(2,4-difluorophenyl)-1-hexanone

HRID 344259

反応式

HRID 344259 の反応式
[Cl-].[Al+3].[Cl-].[Cl-].[Br:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11](Cl)=[O:12].Cl.[F:15][C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([F:22])[CH:17]=1>>[Br:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]([C:19]1[CH:20]=[CH:21][C:16]([F:15])=[CH:17][C:18]=1[F:22])=[O:12]

参加物

5

反応物 4

HCID 313Hydrochloric AcidHCID 97411,3-DifluorobenzeneHCID 898486-Bromohexanoyl chlorideHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 544758096-Bromo-1-(2,4-difluorophenyl)-1-hexanone

実験手順

Aluminum chloride (1.31 g) was added to a solution of 6-bromohexanoyl chloride (2 g) in 1,3-difluorobenzene (20 ml) under ice-cooling and the mixture was stirred at room temperature for 2 hr. Ice water and conc. hydrochloric acid were added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and brine, dried and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography to give 1.16 g of 6-bromo-1-(2,4-difluorophenyl)-1-hexanone.

後処理

  1. temperaturecooling
  2. extractionthe mixture was extracted with ethyl acetate
  3. washThe organic layer was washed with water and brine
  4. customdried
  5. customthe solvent was evaporated under reduced pressure
  6. customThe obtained residue was purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-b25b40d96be944df8711aacd4df2724f
出典データセット
uspto-grants-1999_01
特許番号
US05864039

関連ノート

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