Potassium Carbonate → 4-Methoxy-1-(6-oxo-6-phenylhexyl)-4-tert-butoxycarbonylaminomethylpiperidine

HRID 344274ノート

反応式

HRID 344274 の反応式
[CH3:1][O:2][C:3]1([CH2:9][NH:10][C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1.Br[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)=[O:25].C(=O)([O-])[O-].[K+].[K+]>>[CH3:1][O:2][C:3]1([CH2:9][NH:10][C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:4][CH2:5][N:6]([CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][C:24](=[O:25])[C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH2:7][CH2:8]1

参加物

4

反応物 3

HCID 11430Potassium CarbonateHCID 112422601-Hexanone, 6-bromo-1-phenyl-HCID 54295846tert-butyl N-[(4-methoxypiperidin-4-yl)methyl]carbamate

生成物 1

HCID 545499604-Methoxy-1-(6-oxo-6-phenylhexyl)-4-tert-butoxycarbonylaminomethylpiperidine収率 85%

実験手順

4-Methoxy-4-tert-butoxycarbonylaminomethylpiperidine (2.3 g), 6-bromo-1-phenyl-1-hexanone (2.52 g) and potassium carbonate (2.6 g) were reacted and treated in the same manner as in Preparation Example 138(1) to give 3.35 g of 4-methoxy-1-(6-oxo-6-phenylhexyl)-4-tert-butoxycarbonylaminomethylpiperidine.

出典と根拠

ORDレコード
ord-9a76fb4e7079414791a40632d76a68c6
出典データセット
uspto-grants-1999_01
特許番号
US05864039

反応ノート

読み込み中…