N-(6-Bromohexyl)phthalimide → 4-amino-5-chloro-N-(1-(6-(2,3-dihydro-1,3-dioxo-1H-isoindol-2-yl)hexyl)-piperidin-4-ylmethyl)-2-methoxybenzamide

HRID 344281ノート

反応式

HRID 344281 の反応式
Cl.Cl.[NH2:3][C:4]1[C:19]([Cl:20])=[CH:18][C:7]([C:8]([NH:10][CH2:11][CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[O:9])=[C:6]([O:21][CH3:22])[CH:5]=1.Br[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][N:30]1[C:34](=[O:35])[C:33]2=[CH:36][CH:37]=[CH:38][CH:39]=[C:32]2[C:31]1=[O:40]>>[NH2:3][C:4]1[C:19]([Cl:20])=[CH:18][C:7]([C:8]([NH:10][CH2:11][CH:12]2[CH2:13][CH2:14][N:15]([CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][N:30]3[C:31](=[O:40])[C:32]4[C:33](=[CH:36][CH:37]=[CH:38][CH:39]=4)[C:34]3=[O:35])[CH2:16][CH2:17]2)=[O:9])=[C:6]([O:21][CH3:22])[CH:5]=1

参加物

3

反応物 2

HCID 141120N-(6-Bromohexyl)phthalimideHCID 699663304-amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride

生成物 1

HCID 545206764-amino-5-chloro-N-(1-(6-(2,3-dihydro-1,3-dioxo-1H-isoindol-2-yl)hexyl)-piperidin-4-ylmethyl)-2-methoxybenzamide収率 70.3%

実験手順

4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride (17.0 g) and N-(6-bromohexyl)phthalimide (17.4 g) were reacted and treated in the same manner as in Preparation Example 150 to give 17.0 g of 4-amino-5-chloro-N-(1-(6-(2,3-dihydro-1,3-dioxo-1 H-isoindol-2-yl)hexyl)piperidin-4-ylmethyl)-2-methoxybenzamide.

後処理

  1. additiontreated in the same manner as in Preparation Example 150

出典と根拠

ORDレコード
ord-1ea2fa3300fc433585b1148ad4ac6514
出典データセット
uspto-grants-1999_01
特許番号
US05864039

反応ノート

読み込み中…