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HRID 344284作成日：2026年10月27日
Potassium Carbonate → 1-(3-Ethylenedioxy-3-(4-methoxyphenyl)propyl)-4-(tert-butoxycarbonylaminomethyl)piperidine
https://huagongshe.com/reaction/344284
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Tert-butyl (piperidin-4-ylmethyl)carbamate | HCID 723429 | — |
| 反応物 | 3-Ethylenedioxy-3-(4-methoxyphenyl)propyl bromide | HCID 70073196 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 1-(3-Ethylenedioxy-3-(4-methoxyphenyl)propyl)-4-(tert-butoxycarbonylaminomethyl)piperidine | HCID 70076348 | 77.2% |
反応手順
To a solution of 4-(tert-butoxycarbonylaminomethyl)piperidine (9.70 g) in toluene (160 ml) were added 3-ethylenedioxy-3-(4-methoxyphenyl)propyl bromide (13.0 g) and potassium carbonate (18.8 g), and the resulting mixture was stirred at 80° C. for 16.5 hr. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel chromatography (chloroform:methanol=20:1) to give 14.7 g of 1-(3-ethylenedioxy-3-(4-methoxyphenyl)propyl)-4-(tert-butoxycarbonylaminomethyl)piperidine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US05864039 |
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| 出典データセット | uspto-grants-1999_01 |
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| ORD ID | ord-908e6692c395460fbb5ec4b2619b6875 |
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| 出典メモ | uspto-grants-1999_01 |
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