Potassium Carbonate → 4-amino-N-((1-(5-benzylthiopentyl)piperidin-4-yl)methyl)-5-chloro-2-methoxybenzamide
反応式
Cl.Cl.[NH2:3][C:4]1[C:19]([Cl:20])=[CH:18][C:7]([C:8]([NH:10][CH2:11][CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[O:9])=[C:6]([O:21][CH3:22])[CH:5]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:29]([S:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41]Cl)[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1>>[NH2:3][C:4]1[C:19]([Cl:20])=[CH:18][C:7]([C:8]([NH:10][CH2:11][CH:12]2[CH2:13][CH2:14][N:15]([CH2:41][CH2:40][CH2:39][CH2:38][CH2:37][S:36][CH2:29][C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[CH2:16][CH2:17]2)=[O:9])=[C:6]([O:21][CH3:22])[CH:5]=1参加物
4
実験手順
4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride (1.5 g) as starting compound, potassium carbonate (2.2 g) and 5-benzylthiopentyl chloride (1.4 g) were reacted and treated in the same manner as in Example 168 to give 0.57 g of 4-amino-N-((1-(5-benzylthiopentyl)piperidin-4-yl)methyl)-5-chloro-2-methoxybenzamide.