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3-Chloro-1-propyne → 2,4-Diamino-5-[3,4-dimethoxy-5-(2-propynyloxy)benzyl]pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Chloro-1-propyne | HCID 12221 | — |
| 反応物 | 3-Demethyltrimethoprim | HCID 12849769 | — |
| 生成物 | 2,4-Diamino-5-[3,4-dimethoxy-5-(2-propynyloxy)benzyl]pyrimidine | HCID 12849803 | — |
反応手順
The title compound was prepared from 2,4-diamino-5-(3-hydroxy-4,5-dimethoxybenzyl)pyrimidine and propargyl chloride by the procedure of Example 1A. Recrystallization from 95% ethanol gave off-white needles (73%); mp 160°-161°. Anal. Calcd for C16H18N4O3 : C, 61.13; H, 5.77; N, 17.82. Found: C, 60.96; H, 5.80; N, 17.75.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04761475 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-4ed8e272c6db47f483d4fbcdc437693a |
| 出典メモ | uspto-grants-1988_08 |