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4-Bromo-1-phenyl-1-butanone → 4-amino-5-chloro-2-methoxy-N-((1-(4-oxo-4-phenylbutyl)piperidin-4-yl)methyl)benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Bromo-1-phenyl-1-butanone | HCID 90356 | — |
| 反応物 | 4-amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride | HCID 69966330 | — |
| 生成物 | 4-amino-5-chloro-2-methoxy-N-((1-(4-oxo-4-phenylbutyl)piperidin-4-yl)methyl)benzamide | HCID 54563895 | 37% |
反応手順
4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride (7 g) and 4-bromo-1-phenyl-1-butanone (4.93 g) were reacted and treated in the same manner as in Example 172 to give 3.1 g of 4-amino-5-chloro-2-methoxy-N-((1-(4-oxo-4-phenylbutyl)piperidin-4-yl)methyl)benzamide.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05864039 |
| 出典データセット | uspto-grants-1999_01 |
| ORD ID | ord-72def7c9b5314e758058ce1d2238c3ba |
| 出典メモ | uspto-grants-1999_01 |