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8-Aminooctanoic acid → HCID 178512800、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 8-Aminooctanoic acid | HCID 66085 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 3,5-Dimethylpyrazole-1-carboxamidine | HCID 97525 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | HCID 178512800 | HCID 178512800 | — |
反応手順
3,5-dimethyl-pyrazole-1-carboxamidine (100 g; 0.5 Mole) and N,N-diisopropylethyl amine (DIEA) (65 g; 0.5 Mole) were suspended in dioxane (300 ml) and water (115 ml). 8-Amino-octanoic acid (48 cg; 0.3 Mole) was added to the mixture with stirring. The colorless solution was then refluxed for 2 days. The product was filtered and washed with water (3×50 ml).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05053393 |
| 出典データセット | uspto-grants-1991_10 |
| ORD ID | ord-09fff9bddcce4417857cd73a927a9c8f |
| 出典メモ | uspto-grants-1991_10 |