4-Aminopyridine → 4-Acetamidopyridine acetate
反応式
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.[C:8]([O:11][C:12](=[O:14])[CH3:13])(=[O:10])[CH3:9]>>[C:8]([OH:11])(=[O:10])[CH3:9].[C:12]([NH:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1)(=[O:14])[CH3:13]参加物
3
反応条件
- 温度
- 100 °C
実験手順
4-Aminopyridine (101.28 g) and acetic anhydride (110 g) were mixed neat and heated at 100° C. for 1/2 h. The solidified reaction mixture was triturated with acetone, filtered off, and washed with ether to afford 186.48 g of title compound as a white solid in two crops.
後処理
- customThe solidified reaction mixture
- customwas triturated with acetone
- filtrationfiltered off
- washwashed with ether
出典と根拠
- ORDレコード
- ord-70630576f7fa4fdf9a289b0a26d56d9a
- 出典データセット
- uspto-grants-1991_10
- 特許番号
- US05053413
反応ノート
読み込み中…