Hydrochloric Acid → Toluene, alpha-chloro-2,3,4-trimethoxy-

HRID 344708

反応式

HRID 344708 の反応式
[CH3:1][O:2][C:3]1[C:10]([O:11][CH3:12])=[C:9]([O:13][CH3:14])[CH:8]=[CH:7][C:4]=1[CH2:5]O.[ClH:15]>O>[CH3:1][O:2][C:3]1[C:10]([O:11][CH3:12])=[C:9]([O:13][CH3:14])[CH:8]=[CH:7][C:4]=1[CH2:5][Cl:15]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 123571(2,3,4-Trimethoxyphenyl)methanol

生成物 1

HCID 97491Toluene, alpha-chloro-2,3,4-trimethoxy-

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
0 °C

実験手順

5.0 g (4.34 mmols) of 2,3,4-trimethoxybenzyl alcohol was dropwise added to 10 ml of conc. hydrochloric acid under stirring at 0° C. The mixture was stirred at 0° C. for further 5 minutes. After the reaction, water was added to the mixture followed by extraction of the solution with diethyl ether. The diethyl ether layer was dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to afford 4.80 g of 2,3,4-trimethoxybenzyl chloride as a crude product.

後処理

  1. stirringThe mixture was stirred at 0° C. for further 5 minutes
  2. additionwas added to the mixture
  3. extractionfollowed by extraction of the solution with diethyl ether
  4. dry with materialThe diethyl ether layer was dried over anhydrous sodium sulfate
  5. customthe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-a3a565d166b2461da24bbc4b59201e1e
出典データセット
uspto-grants-1991_10
特許番号
US05053408

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