Carbon Disulfide → [1,3]Thiazolo[5,4-b]pyridine-2(1H)-thione
反応式
[NH2:1][C:2]1[C:3](Cl)=[N:4][CH:5]=[CH:6][CH:7]=1.[C:9](=[S:11])=[S:10]>CN(C=O)C>[NH:1]1[C:2]2[CH:7]=[CH:6][CH:5]=[N:4][C:3]=2[S:11][C:9]1=[S:10]参加物
4
実験手順
A mixture of 6.43 g (50.0 mmols) of 3-amino-2-chloropyridine, 50 ml of carbon disulfide and 50 ml of DMF was heated under reflux for 6 days. An excess of carbon disulfide was evaporated under reduced pressure, and the residue was poured into 300 ml of ice water with stirring. The precipitated crystals was taken out by filtration and dried to afford 7.57 g (yield: 90%) of pyrido[3,2-d]thiazo-line-2-thione.
後処理
- temperaturewas heated
- temperatureunder reflux for 6 days
- customAn excess of carbon disulfide was evaporated under reduced pressure
- additionthe residue was poured into 300 ml of ice water
- filtrationThe precipitated crystals was taken out by filtration
- customdried
出典と根拠
- ORDレコード
- ord-8942ed11f1d2461db98673c7d5d75d84
- 出典データセット
- uspto-grants-1991_10
- 特許番号
- US05053408
反応ノート
読み込み中…