Urea → 6,7,8-Trimethoxyquinazoline-2,4(1H,3H)-dione

HRID 344712ノート

反応式

HRID 344712 の反応式
[CH3:1][O:2][C:3]1[C:11]([O:12][CH3:13])=[C:10]([O:14][CH3:15])[CH:9]=[C:5]([C:6]([OH:8])=O)[C:4]=1[NH2:16].[NH2:17][C:18](N)=[O:19]>O>[CH3:15][O:14][C:10]1[CH:9]=[C:5]2[C:4](=[C:3]([O:2][CH3:1])[C:11]=1[O:12][CH3:13])[NH:16][C:18](=[O:19])[NH:17][C:6]2=[O:8]

参加物

4

反応物 2

HCID 1176UreaHCID 966023,4,5-Trimethoxyanthranilic acid

生成物 1

HCID 57434216,7,8-Trimethoxyquinazoline-2,4(1H,3H)-dione収率 45.1%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
145 °C

実験手順

A mixture of 4.94 g (21.7 mmols) of 3,4,5-trimethoxyanthranilic acid and 15.15 g (249.8 mmols) of urea was heated at 145° C for an hour with stirring. After cooling, water was added and the mixture was heated at the boiling point with stirring. The solid was taken out by filtration and dried to afford 2.47 g (yield: 45%) of 6,7,8-trimethoxyquinazoline-2,4-dione.

後処理

  1. temperatureAfter cooling
  2. temperaturethe mixture was heated at the boiling point
  3. stirringwith stirring
  4. filtrationThe solid was taken out by filtration
  5. customdried

出典と根拠

ORDレコード
ord-a2fb4af130ef44948c9087476214cf59
出典データセット
uspto-grants-1991_10
特許番号
US05053408

反応ノート

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