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Ammonium Hydroxide → 5-Pyrimidinecarboxylic acid, 4-amino-2-(methylthio)-, ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonium Hydroxide | HCID 14923 | — |
| 反応物 | 4-Chloro-2-(methylthio)pyrimidine-5-carboxylic acid ethyl ester | HCID 80008 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 5-Pyrimidinecarboxylic acid, 4-amino-2-(methylthio)-, ethyl ester | HCID 222666 | — |
反応手順
To a suspension of ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate (25 g) in ethanol (200 mL) was added 30% ammonium hydroxide (38 mL). After stirring 5 hours at room temperature, the reaction was concentrated in vacuo. The residue was suspended in water and filtered. The filter pad, washed with water then diethyl ether, gave 17.68 g of the title compound, CIMS (1% NH3 in CH4): 242=M+ +C2H5, 214=M+ +H (Base), 213=M+, 168=M+ -OEt.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05733913 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-f60b9d4041c0469591d62275b8e1d8d7 |
| 出典メモ | uspto-grants-1998_03 |