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p-Toluenesulfonic acid → 4'-[(S)-2-methylbutoxycarbonyl]biphenyl-4-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | p-Toluenesulfonic acid | HCID 6101 | — |
| 反応物 | 4'-Hydroxy-4-biphenylcarboxylic acid | HCID 301556 | — |
| 反応物 | (S)-2-methyl-1-butanol | HCID 2723602 | — |
| 生成物 | 4'-[(S)-2-methylbutoxycarbonyl]biphenyl-4-ol | HCID 13907538 | 41% |
反応手順
3.75 g of 4-hydroxybiphenyl-4'-carboxylic acid was heated under reflux together with (S)-2-methylbutyl alcohol in the presence of 0.10 g of p-toluenesulfonic acid for about 6 hours. Then the mixture was filtered to remove the unreacted 4-hydroxybiphenyl-4'-carboxylic acid. Next, the filtrate was evaporated and the unreacted (S)-2-methylbutyl alcohol was distilled off. The crystals thus obtained were recrystallized from 200 ml of n-hexane. Thus, 2.05 g of the corresponding colorless compound was obtained (Yield: 41%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05055225 |
| 出典データセット | uspto-grants-1991_10 |
| ORD ID | ord-cf17dec162e3440886c834555d7b68d0 |
| 出典メモ | uspto-grants-1991_10 |