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1,1'-Carbonyldiimidazole → 1-(1H-Imidazol-1-yl)methyl-8-(N-phenyl-(4-hydroxybutyl)amino)imidazo[1,5-a]pyrido[3,4-e]pyrazin-4(5H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 反応物 | 2,4-Dichloro-5-nitropyridine | HCID 12275765 | — |
| 反応物 | N-phenyl-4-hydroxybutylamine | HCID 13755485 | — |
| 反応物 | 2-(1H-imidazol-1-ylmethyl)-1H-imidazole | HCID 19358846 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 生成物 | 1-(1H-Imidazol-1-yl)methyl-8-(N-phenyl-(4-hydroxybutyl)amino)imidazo[1,5-a]pyrido[3,4-e]pyrazin-4(5H)-one | HCID 19809415 | — |
反応手順
Treat 2,4-dichloro-5-nitropyridine with 2-((imidazol-1-yl)methyl)imidazole followed by reaction with N-phenyl-4-hydroxybutylamine, hydrogenation with palladium on carbon and cyclization with carbonyldiimidazole to provide the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05055465 |
| 出典データセット | uspto-grants-1991_10 |
| ORD ID | ord-7bcb811284c649ddac8a879a18b7556b |
| 出典メモ | uspto-grants-1991_10 |