Trichloroacetyl chloride → N-(3-chloro)allyl-N-methoxyethyl trichloroacetamide

N-(3-chloro)allyl-N-methoxyethylamine (2.25 g, 0.015 mol) and 1.52 g (0.015 mol) triethylamine were stirred in 70 ml dichloromethane. The reaction was kept at approximately 5° C. with an ice-water bath. Trichloroacetyl chloride (2.73 g, 0.015 mol) in 10 ml dichloromethane was added dropwise to the cooled solution. Upon completion of the addition, the mixture was stirred at room temperature for 6 hours. The reaction mixture was then washed twice with saturated brine and dried with sodium sulfate. Rotary evaporation yielded 4.1 g of the above-named product.

1. customThe reaction was kept at approximately 5° C. with an ice-water bath
2. additionUpon completion of the addition
3. washThe reaction mixture was then washed twice with saturated brine
4. dry with materialdried with sodium sulfate
5. customRotary evaporation

ORDレコード

ord-8acb45df98e14c3a9a8f3a881c597456

出典データセット

uspto-grants-1988_08

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US04762548