Ammonia → Naphthalenesulfonamide

HRID 345105

反応式

HRID 345105 の反応式
[NH3:1].[C:2]1([S:12](Cl)(=[O:14])=[O:13])[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][CH:3]=1>CCOCC>[C:2]1([S:12]([NH2:1])(=[O:14])=[O:13])[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 222AmmoniaHCID 665601-Naphthalenesulfonyl chloride

生成物 1

HCID 163571Naphthalenesulfonamide収率 70%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

Ammonia was passed (for 5 min) into a stirred solution of 1-naphthalenesulfonyl chloride (5.0 g, 22 mmol) and anhydrous Et2O (400 ml) at -78°. The resulting mixture was stirred at -78° for 1 hr, allowed to warm to room temperature, and stirred overnight. The Et2O was removed under vacuum to leave a white powder which was washed with water and dried under vacuum to give 3.2 g (70%) of the title compound as a white powder, m.p. 152°-153° C.

後処理

  1. custom(for 5 min)
  2. customat -78°
  3. stirringstirred overnight
  4. customThe Et2O was removed under vacuum
  5. customto leave a white powder which
  6. washwas washed with water
  7. customdried under vacuum

出典と根拠

ORDレコード
ord-7e4b5ab5aa724026b7222ee264a74f9c
出典データセット
uspto-grants-1991_10
特許番号
US05055450

関連ノート

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