Acetic Acid → 3-(Acetyloxy)-2-[(acetyloxy)methyl]-2-methylpropanoic acid

HRID 34518

反応式

HRID 34518 の反応式
[OH:1][CH2:2][C:3]([CH2:8][OH:9])([CH3:7])[C:4]([OH:6])=[O:5].[C:10](OC(=O)C)(=[O:12])[CH3:11].[C:17](O)(=[O:19])[CH3:18]>>[C:10]([O:1][CH2:2][C:3]([CH2:8][O:9][C:17](=[O:19])[CH3:18])([CH3:7])[C:4]([OH:6])=[O:5])(=[O:12])[CH3:11]

参加物

4

反応物 3

HCID 176Acetic AcidHCID 7918Acetic AnhydrideHCID 78501Dimethylolpropionic acid

生成物 1

HCID 224578423-(Acetyloxy)-2-[(acetyloxy)methyl]-2-methylpropanoic acid

実験手順

268 g (2 moles) of 2,2-bis-hydroxymethyl propionic acid are refluxed for 10 hours in 800 ml of glacial acetic acid and 416 ml (4.4 moles) of acetic acid anhydride. The reaction solution is freed from the solvent in vacuo. The oily residue is stirred with 1500 ml of petroleum ether, the carboxylic acid ester is crystallizing out. It is filtered off under suction and washed with petroleum ether. Yield 420 g (96% of the theoretical); Mp. 85° C.

後処理

  1. customthe carboxylic acid ester is crystallizing out
  2. filtrationIt is filtered off under suction
  3. washwashed with petroleum ether

出典と根拠

ORDレコード
ord-514729e647c04c69a19605290443db05
出典データセット
uspto-grants-1988_08
特許番号
US04762777

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