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Methyl propiolate → ethyl 2-oxo-2H-pyrimido[2,1-b]benzothiazole-8-acetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl propiolate | HCID 13536 | — |
| 反応物 | (2-Amino-benzothiazol-6-yl)-acetic acid ethyl ester | HCID 821202 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | ethyl 2-oxo-2H-pyrimido[2,1-b]benzothiazole-8-acetate | HCID 13477942 | 48% |
反応手順
A stirred mixture of 5 g of ethyl 2-aminobenzothiazole-6-acetate [prepared according to Sawhney et al., Ind J. Chem., Vol. 16B p. 605 (1978)], 1.95 g of methyl propiolate and 30 ml of ethanol was heated under reflux for 2 hours and the mixture was allowed to cool. The crude product was collected and then recrystallized from n-butyl alcohol to obtain 2.88 g of ethyl 2-oxo-2H-pyrimido[2,1-b]benzothiazole-8-acetate as yellow needles (48% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04762840 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-a1b92139392b4104a22c17f1bae70340 |
| 出典メモ | uspto-grants-1988_08 |