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1-Methylcyclohexyl 2-(p-nitrophenyl)propionate → 1-Methylcyclohexyl 2-(p-aminophenyl)-propionate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Methylcyclohexyl 2-(p-nitrophenyl)propionate | HCID 54068492 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 1-Methylcyclohexyl 2-(p-aminophenyl)-propionate | HCID 13754071 | 67.1% |
反応手順
A stirred solution of 34.9 g of 1-methylcyclohexyl 2-(p-nitrophenyl)-propionate in 250 ml of absolute ethanol was hydrogenated at atmospheric pressure in the presence of 10% palladium on carbon catalyst. After the uptake of hydrogen gas was complete, the catalyst was filtered off through celite and the filtrate was evaporated to dryness. Trituration of the residue with petroleum ether gave 21.02 g (67% yield) of 1-methylcyclohexyl 2-(p-aminophenyl)-propionate as creamy white crystals melting at 85°-87° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04762840 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-15fc9e5b04644708b922aada49328d83 |
| 出典メモ | uspto-grants-1988_08 |