N-[4-([1-(Benzyloxycarbonyl)piperidin-4-yl]methoxy)phenyl]methanesulphonamide → N-[4-([Piperidin-4-yl]methoxy)phenyl]methanesulphonamide
反応式
C(OC([N:11]1[CH2:16][CH2:15][CH:14]([CH2:17][O:18][C:19]2[CH:24]=[CH:23][C:22]([NH:25][S:26]([CH3:29])(=[O:28])=[O:27])=[CH:21][CH:20]=2)[CH2:13][CH2:12]1)=O)C1C=CC=CC=1>C(O)C>[NH:11]1[CH2:16][CH2:15][CH:14]([CH2:17][O:18][C:19]2[CH:24]=[CH:23][C:22]([NH:25][S:26]([CH3:29])(=[O:28])=[O:27])=[CH:21][CH:20]=2)[CH2:13][CH2:12]1参加物
3
実験手順
A solution of the product of part (iv) (0.15 g) in ethanol was hydrogenated at 50° and 3.5 bar in the presence of 5% palladium on carbon until the required amount of hydrogen had been absorbed. The catalyst was filtered off and washed several times with hot ethanol. The combined filtrate and washings were evaporated to give the product, (0.10 g), m.p. 180°-183°, which was used without further purification.
後処理
- customwas hydrogenated at 50°
- custom