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Triethylamine → 5-Fluoro-1-methylcarbamoylisatin
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Methyl Isocyanate | HCID 12228 | — |
| 反応物 | 5-Fluoroisatin | HCID 236566 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 5-Fluoro-1-methylcarbamoylisatin | HCID 14229948 | 74.5% |
反応手順
A mixture of 5-fluoroisatin (9.9 g), triethylamine (1 ml) and dimethylformamide (30 ml) is stirred under ice-cooling, and thereto is added dropwise methyl isocyanate (3 g) at the same temperature. The mixture is stirred at room temperature for 30 minutes, and the precipitates are taken by filtration to give 5-fluoro-1-methylcarbamoylisatin (8.7 g). M.p. 230°-232° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04762839 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-c25576f7a14c4b82ae9916dfb75fb8cd |
| 出典メモ | uspto-grants-1988_08 |