Triethylamine → 5-Fluoro-1-methylcarbamoylisatin

HRID 34552

反応式

HRID 34552 の反応式
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=[O:12].C(N(CC)CC)C.[CH3:20][N:21]=[C:22]=[O:23]>CN(C)C=O>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([C:22](=[O:23])[NH:21][CH3:20])[C:6](=[O:11])[C:5]2=[O:12]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 12228Methyl IsocyanateHCID 2365665-Fluoroisatin

生成物 1

HCID 142299485-Fluoro-1-methylcarbamoylisatin収率 74.5%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 5-fluoroisatin (9.9 g), triethylamine (1 ml) and dimethylformamide (30 ml) is stirred under ice-cooling, and thereto is added dropwise methyl isocyanate (3 g) at the same temperature. The mixture is stirred at room temperature for 30 minutes, and the precipitates are taken by filtration to give 5-fluoro-1-methylcarbamoylisatin (8.7 g). M.p. 230°-232° C.

後処理

  1. temperaturecooling
  2. stirringThe mixture is stirred at room temperature for 30 minutes
  3. filtrationthe precipitates are taken by filtration

出典と根拠

ORDレコード
ord-c25576f7a14c4b82ae9916dfb75fb8cd
出典データセット
uspto-grants-1988_08
特許番号
US04762839

関連ノート

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