化工社化工社 化学情報印刷レポート · 研究参考用
Imidazole → Ethyl 4-(1H-imidazol-1-yl)benzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Imidazole | HCID 795 | — |
| 反応物 | Potassium Iodide | HCID 4875 | — |
| 反応物 | Dimethylacetamide | HCID 31374 | — |
| 反応物 | Benzoic acid, 4-fluoro-, ethyl ester | HCID 67976 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Ethyl 4-(1H-imidazol-1-yl)benzoate | HCID 13423940 | 33.3% |
反応手順
A mixture of 13.6 parts of 1H-imidazole, 16.8 parts of ethyl 4-fluorobenzoate, 0.1 parts of potassium iodide and 54 parts of N,N-dimethylacetamide was stirred and refluxed for 20 hours. The reaction mixture was cooled to room temperature and poured onto a lot of water. The product was extracted a few times with benzene. The combined extracts were washed thoroughly with water, dried, filtered and evaporated. The residue was stirred in hexane. The product was filtered off and dried, yielding 7.2 parts (33.3%) of ethyl 4-(1H-imidazol-1-yl)benzoate; mp. 100.3° C. (intermediate 18).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05057525 |
| 出典データセット | uspto-grants-1991_10 |
| ORD ID | ord-30bea23f83bd45a6a20762b1f619e7ef |
| 出典メモ | uspto-grants-1991_10 |