Hydrochloric Acid → (+)-cis-3-methoxy-N-(1-phenylethyl)-4-piperidinamine

HRID 345577ノート

反応式

HRID 345577 の反応式
[CH3:1][O:2][C@H:3]1[C@@H:8]([NH:9][CH:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH3:11])[CH2:7][CH2:6][N:5](C(OCC)=O)[CH2:4]1.Cl>>[CH3:1][O:2][C@H:3]1[C@@H:8]([NH:9][CH:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH3:11])[CH2:7][CH2:6][NH:5][CH2:4]1

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 67914576(+)-Ethyl cis-3-methoxy-4-[(1-phenylethyl)amino]-1-piperidinecarboxylate

生成物 1

HCID 67914506(+)-cis-3-methoxy-N-(1-phenylethyl)-4-piperidinamine収率 100%

実験手順

A solution of 16 parts of (+)-ethyl cis-3-methoxy-4-[(1-phenylethyl)amino]-1-piperidinecarboxylate in 170 parts of a hydrochloric acid solution 6N was stirred and refluxed for 45 hours. The reaction mixture was cooled and washed with dichloromethane. The aqueous phase was cooled in an ice-bath and treated with ammonium hydroxide. The product was extracted three times with 130 parts of dichloromethane. The combined extracts were washed with 10 parts of water, dried, filtered and evaporated. The residue was dissolved in methylbenzene and the latter was evaporated again, yielding 12.2 parts (100%) of (+)-cis-3-methoxy-N-(1-phenylethyl)-4-piperidinamine as a residue (intermediate 105).

後処理

  1. temperaturerefluxed for 45 hours
  2. temperatureThe reaction mixture was cooled
  3. washwashed with dichloromethane
  4. temperatureThe aqueous phase was cooled in an ice-bath
  5. additiontreated with ammonium hydroxide
  6. extractionThe product was extracted three times with 130 parts of dichloromethane
  7. washThe combined extracts were washed with 10 parts of water
  8. customdried
  9. filtrationfiltered
  10. customevaporated
  11. dissolutionThe residue was dissolved in methylbenzene
  12. customthe latter was evaporated again

出典と根拠

ORDレコード
ord-1d4483c24d8346c4b2c70aefb4ba4130
出典データセット
uspto-grants-1991_10
特許番号
US05057525

反応ノート

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