Potassium Carbonate → Ethyl 1-cyclopropyl-6,8-difluoro-7-methyl-1,4-dihydro-4-oxo-3-quinolinecarboxylate
反応式
C(=O)([O-])[O-].[K+].[K+].Cl[C:8]1[C:26]([F:27])=[C:25]([CH3:28])[C:24]([F:29])=[CH:23][C:9]=1[C:10]([C:12](=[CH:18][NH:19][CH:20]1[CH2:22][CH2:21]1)[C:13]([O:15][CH2:16][CH3:17])=[O:14])=[O:11]>CN(C)C=O>[CH:20]1([N:19]2[C:23]3[C:9](=[CH:8][C:26]([F:27])=[C:25]([CH3:28])[C:24]=3[F:29])[C:10](=[O:11])[C:12]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:18]2)[CH2:22][CH2:21]1参加物
4
実験手順
16.5 g of potassium carbonate are added to a solution of 37.7 g of ethyl 2-(2-chloro-3,5-difluoro-4-methylbenzoyl)-3-cyclopropylamino-acrylate in 100 ml of anhydrous dimethylformamide. The reaction mixture is then stirred under reflux for 2 hours and poured hot onto ice. The precipitate is filtered off with suction, washed thoroughly with water and dried in vacuo over calcium chloride at 100° C. 30.4 g of ethyl 1-cyclopropyl-6,8-difluoro-7-methyl-1,4-dihydro-4-oxo-3-quinolinecarboxylate of melting point 177°-179° C. are obtained.