Ammonia → 5-Ethynyl-1-pentofuranosyl-1H-imidazole-4-carboximidic acid

HRID 345754ノート

反応式

HRID 345754 の反応式
C[Si](C)(C)[C:3]#[C:4][C:5]1[N:9]([C@@H:10]2[O:22][C@H:21]([CH2:23][O:24]C(=O)C)[C@@H:16]([O:17]C(=O)C)[C@H:11]2[O:12]C(=O)C)[CH:8]=[N:7][C:6]=1[C:28]([NH2:30])=[O:29].N>CO>[C:4]([C:5]1[N:9]([C@@H:10]2[O:22][C@H:21]([CH2:23][OH:24])[C@@H:16]([OH:17])[C@H:11]2[OH:12])[CH:8]=[N:7][C:6]=1[C:28]([NH2:30])=[O:29])#[CH:3]

参加物

4

反応物 2

HCID 222AmmoniaHCID 14158666HCID 14158666、化合物

生成物 1

HCID 4531805-Ethynyl-1-pentofuranosyl-1H-imidazole-4-carboximidic acid収率 87.1%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

400 mg of the glutinous substance obtained in (1) was added to a solvent mixture of aqueous ammonia and methanol and, after the mixture was left to stand overnight, the solvent was evaporated. The residue obtained was adsorbed onto a silica gel column (2.3×13 cm), eluted with a 5-10% ethanol-chloroform solvent mixture and crystallized from ethanol to obtain 200 mg of white crystals (yield: 87.1%).

後処理

  1. waitafter the mixture was left
  2. customthe solvent was evaporated
  3. customThe residue obtained
  4. washeluted with a 5-10% ethanol-chloroform solvent mixture
  5. customcrystallized from ethanol

出典と根拠

ORDレコード
ord-3edfd8a9f9a34b37b62757abd19f9398
出典データセット
uspto-grants-1991_10
特許番号
US05059590

反応ノート

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