化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 3-Amino-2-chloro-5-fluoro-4-methylbenzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Sodium Dithionite | HCID 24489 | — |
| 反応物 | 2-Chloro-5-fluoro-4-methyl-3-nitro-benzoic acid | HCID 13657439 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | 2-Methoxyethanol | HCID 8019 | — |
| 生成物 | 3-Amino-2-chloro-5-fluoro-4-methylbenzoic acid | HCID 13657440 | — |
反応手順
18.5 g of 2-chloro-5-fluoro-4-methyl-3-nitro-benzoic acid and 51.5 g of Na2S2O4 are boiled in a mixture of 160 ml of glycol monomethyl ether and 160 g of water for 3 hours. 230 ml of 1/2-concentrated HCl are added to the still warm solution. The mixture is boiled up once more, cooled and poured into 560 ml of water. The solid which has precipitated is isolated and dried. Yield: 12.4 g, melting point: 182°-84°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04762844 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-59d9ecf81f1c4d51bdbef875b42cf00b |
| 出典メモ | uspto-grants-1988_08 |