Ammonia → trans-3-Amino-1-benzyl-4-hydroxy-pyrrolidine
反応式
[CH2:1]([N:8]1[CH2:13][CH:12]2[CH:10]([O:11]2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH3:14]>>[NH2:14][C@H:10]1[C@H:12]([OH:11])[CH2:13][N:8]([CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[CH2:9]1参加物
3
実験手順
8.9 g (50 mmol) of 3-benzyl-6-oxa-3-azabicyclo[3.1.0]hexane are heated in 75 ml of ammonia solution (25% strength) at 120° C. in an autoclave for 8 hours. The solution is concentrated and the residue is distilled.
後処理
- concentrationThe solution is concentrated
- distillationthe residue is distilled
出典と根拠
- ORDレコード
- ord-eebc91b05ec6422db65764e7a3f98e83
- 出典データセット
- uspto-grants-1991_10
- 特許番号
- US05059597
反応ノート
読み込み中…