Ethyl 3-(hydroxymethyl)-4-(methylamino)pyrrolidine-1-carboxylate → (4-(Methylamino)pyrrolidin-3-yl)methanol
反応式
[OH:1][CH2:2][CH:3]1[CH2:7][N:6](C(OCC)=O)[CH2:5][CH:4]1[NH:13][CH3:14]>O>[OH:1][CH2:2][CH:3]1[CH2:7][NH:6][CH2:5][CH:4]1[NH:13][CH3:14]参加物
3
実験手順
34 g (0.168 mol) of ethyl 4-hydroxymethyl-3-methylaminopyrrolidine-1-carboxylate are heated under reflux with 100 g of Ba(OH)2.8H2O in 400 ml of water overnight. The BaCO3 is filtered off with suction, the filtrate is concentrated and the residue is boiled up ten times with 100 ml of dioxane each time. The dioxane solutions are filtered, the filtrate is concentrated and the residue is distilled.
後処理
- filtrationThe BaCO3 is filtered off with suction
- concentrationthe filtrate is concentrated
- filtrationThe dioxane solutions are filtered
- concentrationthe filtrate is concentrated
- distillationthe residue is distilled
出典と根拠
- ORDレコード
- ord-743186480377457e9f84c1c5ce44704a
- 出典データセット
- uspto-grants-1991_10
- 特許番号
- US05059597
反応ノート
読み込み中…