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Hydrochloric Acid → 4-Aminobenzoic Acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | Sodium Dithionite | HCID 24489 | — |
| 反応物 | 2,4-Dichloro-3-methyl-5-nitrobenzoic acid | HCID 13657443 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | 2-Methoxyethanol | HCID 8019 | — |
| 生成物 | 4-Aminobenzoic Acid | HCID 978 | — |
反応手順
55 g of 2,4-dichloro-3-methyl-5-nitrobenzoic acid and 141.6 g of Na2S2O4 are boiled in a mixture of 440 ml of glycol monomethyl ether and 440 ml of water for 3 hours. 620 ml of 1/2-concentrated HCl are added to the still warm solution and the mixture is then boiled up once more. After cooling to room temperature, the mixture is poured into 1.5 l of water and brought to pH 5 with sodium carbonate. 24.6 g of aminobenzoic acid are obtained. Melting point: 202°-3°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04762844 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-5b626c226c2642a5a780bd9dbe3f6026 |
| 出典メモ | uspto-grants-1988_08 |